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Nutritional Supplement

Manganese

Manganese is an essential trace mineral needed for healthy skin, bone, and cartilage formation, as well as glucose tolerance. It also helps activate superoxide dismutase (SOD)—an important antioxidant enzyme.

References

1. National Research Council. Recommended Dietary Allowances. 10th ed. Washington, DC: National Academy Press, 1989.

2. Raloff J. Reasons for boning up on manganese. Science News 1986;Sep 27:199 [review].

3. Nagatomo S, Umehara F, Hanada K, et al. Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. J Neurol Sci 1999;162:102-5.

4. Ejima A, Imamura T, Nakamura S, et al. Manganese intoxication during total parenteral nutrition. Lancet 1992;339:426 [letter].

5. Fell JM, Reynolds AP, Meadows N, et al. Manganese toxicity in children receiving long-term parenteral nutrition. Lancet 1996;347:1218-21.

6. Ferraz HB, Bertolucci PH, Pereira JS, et al. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 1988;38:550-3.

7. Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4.

8. Staunton M, Phelan DM. Manganese toxicity in a patient with cholestasis receiving total parenteral nutrition. Anaesthesia 1995;50:665.

9. Rubenstein AH, Levin NW, Elliott GA. Hypoglycaemia induced by manganese. Nature (London) 1962;194:188-9.

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