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Asian Ginseng > Interactions

Nutritional Supplement

Asian Ginseng

Also indexed as:Ginseng (Asian), Panax ginseng, Asian Ginseng Root, Ren Shen

  • Negative Interactions

    3

    • Asian Ginseng

      Imatinib

      Potential Negative Interaction

      A case report suggested that Panax ginseng may inhibit the metabolism of imatinib, potentially increasing the toxicity of the drug. People taking imatinib should therefore not take Panax ginseng.

      Imatinib
      Asian Ginseng
      ×
      1. Bilgi N, Bell K, Ananthakrishnan AN, Atallah E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother 2010;44:926-8.

    • Asian Ginseng

      Ticlopidine

      Potential Negative Interaction

      Ginseng (Panax ginseng) was associated with a decrease in warfarin activity in a case study. This report suggests that ginseng may affect parameters of bleeding. Therefore, people taking ticlopidine should consult with a physician knowledgeable about botanical medicines before taking Asian ginseng or eleuthero/Siberian ginseng (Eleutherococcus senticosus).

      Ticlopidine
      Asian Ginseng
      ×
      1. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3.

    • Asian Ginseng

      Warfarin

      Potential Negative Interaction

      Asian ginseng was associated with a decrease in warfarin activity in a case report. However, in a clinical trial, no interaction was seen between Asian ginseng and warfarin. An animal study also found no significant interaction between warfarin and pure ginseng extract. Nevertheless, persons taking warfarin should consult with a physician knowledgeable about botanical medicines if they are considering taking Asian ginseng or eleuthero/Siberian ginseng (Eleutherococcus senticosus). A 1999 animal study did not reveal any significant interaction between warfarin and pure ginseng extract.

      Warfarin
      Asian Ginseng
      ×
      1. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3.
      2. Lee SH, Ahn YM, Ahn SY, et al. Interaction between warfarin and Panax ginseng in ischemic stroke patients. J Altern Complement Med 2008;14:715-21.
      3. Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Pharm Pharmacol 1999;51:175-80.

  • Supportive Interactions

    3

    • Asian Ginseng

      Chlorphen-Pyrilamine-PE Tannts

      Support Medicine

      Laboratory studies have shown that compounds found in Panax ginseng enhance the ability of phenylephrine to constrict blood vessels. Controlled studies are necessary to determine whether taking Panax ginseng at the same time as phenylephrine will enhance the beneficial effects of the drug.

      Chlorphen-Pyrilamine-PE Tannts
      Asian Ginseng
      ×
      1. Kwan CY. Vascular effects of selected antiphypertensive drugs derived from traditional medicinal herbs. Clin Exp Pharmacol Physiol 1995;22 Suppl 1:S297-9.

    • Asian Ginseng

      Influenza Virus Vaccine

      Support Medicine

      In a randomized, double-blind study, 227 people received influenza vaccine plus 100 mg of standardized extract of Asian ginseng (Panax ginseng) or placebo two times per day for four weeks before and eight weeks after influenza vaccination. Compared with placebo, Asian ginseng extract was reported to prevent colds and flu, improve immune cell activity, and increase antibody levels after vaccination.

      Influenza Virus Vaccine
      Asian Ginseng
      ×
      1. Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized ginseng extract G 115 for potentiating vaccination against common cold and/or influenza syndrome. Drugs Exp Clin Res 1996;22:65-72.

    • Sho-Saiko-To (Bupleurum, Peony, Pinellia, Cassia, Ginger, Jujube, Asian Ginseng, Asian Scullcap, and Licorice)

      Lamivudine

      Support Medicine

      Test tube studies show that the herbal combination sho-saiko-to enhances the antiviral activity of lamivudine. Sho-saiko-to contains extracts of seven herbs, including Bupleuri radix, Pinelliae tuber, Scutellariae radix, Zizyphi fructus, ginseng (Ginseng radix),licorice (Glycyrrhizae radix), and ginger (Zingibers rhizoma). Controlled studies are needed to determine whether taking sho-saiko-to might enhance the beneficial effects of lamivudine.

      Lamivudine
      Sho-Saiko-To (Bupleurum, Peony, Pinellia, Cassia, Ginger, Jujube, Asian Ginseng, Asian Scullcap, and Licorice)
      ×
      1. Piras G, Makino M, Baba M. Sho-saiko-to, a traditional kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol 1997;41:835-9.

References

1. Shibata S, Tanaka O, Shoji J, Saito H. Chemistry and pharmacology of Panax. In Economic and Medicinal Plant Research, vol 1, Wagner H, Hikino H, Farnsworth NR (eds). London: Academic Press, 1985, 217-84.

2. Tomoda M, Hirabayashi K, Shimizu N, et al. Characterization of two novel polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16:1087-90.

3. See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 1997;35:229-35.

4. Yun TK, Choi Y. Non-organ specific cancer prevention of ginseng: A prospective study in Korea. Int J Epidemiol 1998;27:359-64.

5. Shin HR, Kim JY, Yun TK, et al. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 2000;11:565-76 [review].

6. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995;18:1373-5.

7. Teves MA, Wright JE, Welch MJ, et al. Effects of ginseng on repeated bouts of exhaustive exercise. Med Sci Sports Exerc 1983;15:162.

8. Allen JD, McLung J, Nelson AG, Welsch M. Ginseng supplementation does not enhance healthy young adults' peak aerobic exercise performance. J Am Coll Nutr 1998;17:462-6.

9. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.

10. Le Gal M, Cathebras P, Struby K. Pharmaton capsules in the treatment of functional fatigue: A double-blind study versus placebo evaluated by a new methodology. Phytother Res 1996;10:49-53.

11. Caso Mardsco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res 1996;22:323-9.

12. Brown D. Licorice root - potential early intervention for chronic fatigue syndrome. Quart Rev Natural Med 1996;Summer:95-7.

13. Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panmineva Med 1996;38:249-54.

14. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impotence Res 1995;7:181-6.

15. Hong B, Ji YH, Hong JH, et al. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3.

16. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impotence Res 1995;7:181-6.

17. Hong B, Ji YH, Hong JH, et al. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3.

18. Choi HK, Seong DH, Rha KH. Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impotence Res 1995;7:181-6.

19. Hong B, Ji YH, Hong JH, et al. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3.

20. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 129-38.

21. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Healthcare Professionals. London: Pharmaceutical Press, 1996, 145-50.

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