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Bacopa > Safety

Nutritional Supplement

Bacopa

Also indexed as:Bacopa monnieri

Side Effects

Bacopa appears to be well tolerated when taken in typical amounts,22 although one double-blind study reported significantly more symptoms of dry mouth, nausea, and muscle fatigue in participants taking bacopa.23

References

1. Chatterji N, Rastorgi RP, Dhar ML. Chemical examination of Bacopa monniera Wettst. Part I: isolation of chemical constituents. Indian J Chem 1963;1:212.

2. Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3—a triterpenoid saponin from Bacopa monniera. Phytochemistry 1994;36:133-7.

3. Jain P, Kulshreshtha DK. Bacoside A1, a minor saponin from Bacopa monniera. Phytochemistry 1993;33:449-51.

4. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29:S359-S365.

5. Singh HK, Rastogi RP, Srimal RC, Dhawan BN. Effect of bacosides A and B on avoidance responses in rats. Phytother Res 1988;2:70-5.

6. Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (brahmi) extract on avoidance responses in rat. J Ethnopharmacol 1982;5:205-14.

7. Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized extract of Bacopa monniera—an experimental study. Phytomedicine 1998;5:77-82.

8. Sairam K, Dorababu M, Goel RK, Bhattacharya SK. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 2002;9:207-11.

9. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001;156:481–4.

10. Bhattacharya SK, Kumar A, Ghosal S. Effect of Bacopa monniera on animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats. In: Siva Sanka DV, ed. Molecular Aspects of Asian Medicine. New York: PJD Publications, 2000.

11. Ganguly GK, Malhtora CL. Some neuropharmacological and behavioral effects of an activefraction from Herpestis monniera Linn (Brahmi). Indian J Physiol Pharmacol 1967;11:33-43.

12. Dey PK, Datta C. Effect of psychotropic phytochemicals on cerebral amino acid level. Indian J Exp Biol 1966; 4:216-8.

13. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res 2000;14:174-9.

14. Russo A, Borrelli F, Campisi A, et al. Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera. Life Sci 2003;73:1517-26.

15. Dar A, Channa S. Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats. Phytomedicine 1997;4:319-23.

16. Dar A, Channa S. Relaxant effect of ethanol extract of Bacopa monniera on trachea, pulmonary artery and aorta from rabbit and guinea-pig. Phytother Res 1997;11:323-5.

17. Channa S, Dar A, Yaqoob M, et al. Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera. J Ethnopharmacol2003;86:27-35.

18. Dar A, Channa S. Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig. J Ethnopharmacol 1999;66:167-74.

19. Sairam K, Rao CV, Babu MD, Goel RK. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 2001;8:423-30.

20. [No author listed].The Wealth of India: Raw Materials. II-B. New Delhi: Publications and Information Directorate, CSIR, 1950:2-3.

21. [No author given]. Indian Herbal Pharmacopoeia,Volume 1. Worli, Mumbai: Indian Drug Manufacturers Association, 1998.

22. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29:S359-S365.

23. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001;156:481–4.

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