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Nutritional Supplement

Schisandra

Parts Used & Where Grown

Schisandra is a woody vine with numerous clusters of tiny, bright red berries. It is distributed throughout northern and northeast China and the adjacent regions of Russia and Korea.1 The fully ripe, sun-dried fruit is used medicinally. It is purported to have sour, sweet, salty, hot, and bitter tastes. This unusual combination of flavors is reflected in schisandra’s Chinese name wu-wei-zi, meaning “five taste fruit.”

How It Works

The major constituents in schisandra are lignans (schizandrin, deoxyschizandrin, gomisins, and pregomisin) found in the seeds of the fruit. Modern Chinese research suggests these lignans have a protective effect on the liver and an immunomodulating effect. Two human trials completed in China (one double-blind and the other preliminary) have shown that schisandra may help people with chronic viral hepatitis.2,3 Schisandra lignans appear to protect the liver by activating the enzymes in liver cells that produce glutathione, an important antioxidant substance.4

References

1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 469-72.

2. Liu KT. Studies on fructus Schisandrae chinensis. Annex 12: Studies on fructus Schisandrae chinensis. Plenary lecture, World Health Organization Seminar on the Use of Medicinal Plants in Health Care, Sept 1977, Tokyo, Japan. In: WHO Regional Office for the Western Pacific Final Report, Manila, 1977, 101-12.

3. Chang HM, But P (eds). Pharmacology and Applications of Chinese Materia Medica 1. Singapore: World Scientific, 1986.

4. Ip SP, Poon MKT, Wu SS, et al. Effect of schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity. Planta Med 1995;61:398-401.

5. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 624-5.

6. Foster S, Yue CX. Herbal Emissaries: Bringing Chinese Herbs to the West. Rochester, VT: Healing Arts Press, 1992, 146-52.

7. McGuffin M, Hobbs C, Upton R, et al. American Herbal Product Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 104.